Geochemistry and clay Mineral assemblages of pre- to post-orogenic coarse clastics of the eastern Afghan-Tajik Depression (Central Asia)

Abstract HKT-ISTP 2013 A

Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor

The integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellular pathway is modulated by tight junctions between adjacent cells. Rupturing its integrity by H2O2 is monitored by the change of the output voltage in the transfer characteristics. It is demonstrated that by operating the OECT in a current-driven configuration, the sensitive and temporal resolution for monitoring the cell barrier integrity is strongly enhanced as compared to the OECT transient response measurement. As a result, current-driven OECTs are useful tools to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening

Self-energy of Lambda in finite nuclei

The self--energy of the strange baryon $\Lambda$ in $^{17}$O is calculated using a microscopic many--body approach which accounts for correlations beyond the mean--field or Hartree--Fock approximation. The non-locality and energy-dependence of the $\Lambda$ self--energy is discussed and the effects on the bound and scattering states are investigated. For the nucleon--hyperon interaction, we use the potential models of the J\"{u}lich and Nijmegen groups.Comment: 17 pages, Revtex Latex style, 7 figs include

State scaling of continuous-time sigma-delta modulators

In this paper, the common method of scaling the feedback coefficients of continuous time sigma delta modulators in order to stabilize the system is enhanced. The presented approach scales the different states of the system instead of the coefficients. The new corresponding coefficients are then calculated from the solution of the state space description. Therewith, it is possible to tune the maximum out-of-band gain directly in continuous time. In addition, the input amplitude distribution between each quantization level of multi bit sigma-delta modulator can be adapted

IslamiCity Creating an Islamic Cybersociety

Since the mid-1990s, Islamic webcontent has grown considerably. The distribution of fatwas, one of the most booming components of Islamic webcontent, is becoming a must for any Islamic website. In 1999 at least 10,000 fatwas were to be found online. In the year 2000 the number rose to at least 14,000 fatwas, and this year thousands more are sure to be added to the score. Since the time of the Prophet Muhammad, the provision of fatwas has been an important social barometer. The interactive component of the internet has made online fatwa services not only possible, but easy and accessible as well. Such virtual services, however, impact certain Islamic beliefs and practices

Monitoring Reversible Tight Junction Modulation with a Current‐Driven Organic Electrochemical Transistor

AbstractThe barrier functionality of a cell layer regulates the passage of nutrients into the blood. Modulating the barrier functionality by external chemical agents like poly‐l‐lysine (PLL) is crucial for drug delivery. The ability of a cell layer to impede the passage of ions through it and therefore to act as a barrier, can be assessed electrically by measuring the resistance across the cell layer. Here, an organic electrochemical transistor (OECT) is used in a current‐driven configuration for the evaluation of reversible modulation of tight junctions in Caco‐2 cells over time. Exposure to low and medium concentrations of PLL initiates reversible modulation, whereas a too high concentration induces an irreversible barrier disruption due to nonfunctional tight junction proteins. The results demonstrate the suitability of OECTs to in situ monitor temporal barrier modulation and recovery, which can offer valuable information for drug delivery applications

The high-intensity hyperon beam at CERN

A high-intensity hyperon beam was constructed at CERN to deliver Sigma- to experiment WA89 at the Omega facility and operated from 1989 to 1994. The setup allowed rapid changeover between hyperon and conventional hadron beam configurations. The beam provided a Sigma-flux of 1.4 x 10^5 per burst at mean momenta between 330 and 345 Gev/c, produced by about 3 x 10^10 protons of 450 GeV/c . At the experiment target the beam had a Sigma-/pi- ratio close to 0.4 and a size of 1.6 x 3.7 cm^2. The beam particle trajectories and their momenta were measured with a scintillating fibre hodoscope in the beam channel and a silicon microstrip detector at the exit of the channel. A fast transition radiation detector was used to identify the pion component of the beam.Comment: 20 pages, 13 figures. Submitted to Nucl. Instr. Meth.